巨细胞病毒(CMV)属于β疱疹病毒亚科,儿童普遍易感,并可引起部分感染患儿发育异常及脏器损害。CMV感染常引起一系列免疫反应,导致机体免疫功能异常。细胞因子参与了CMV感染的发生发展过程。文章描述并讨论在儿童CMV感染中Th1/Th2细胞因子的变化,为儿童CMV的研究及临床治疗提供思路。 Cytomegalovirus (CMV) belongs to beta herpes virus subfamily, children are generally susceptible, and can cause partial infection in children with dysplasia and organ damage. CMV infection often causes a series of immune reactions, leading to abnormal immune function. Cytokines are involved in the development of CMV infection. This article describes and discusses the changes of Th1 / Th2 cytokines in children with CMV infection and provides ideas for the research and clinical treatment of CMV in children.