钙拮抗剂主要通过抑制钙经过心肌和血管平滑肌细胞膜进入细胞而发挥作用。这类药物的舒张血管作用引起抗高血压效应和病人各种血流动力学变化。新的二氢吡啶类钙拮抗剂尼卡的平(Nicardipine)能使正常狗的肾小球滤过率和肾血流量增加,但其对人肾功能的影响则所知甚少。作者研究了尼卡的平对轻中度原发性高血压病人的肾功能的影响。 Calcium antagonists play a role primarily by inhibiting the entry of calcium into the cells through the myocardium and vascular smooth muscle cell membranes. The vasodilatation of these drugs causes antihypertensive effects and various patient hemodynamic changes. Nicardipine, a new dihydropyridine calcium antagonist, increases glomerular filtration rate and renal blood flow in normal dogs, but its effect on human renal function is poorly understood. The authors studied the effects of nicardine on renal function in patients with mild to moderate essential hypertension.