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目的探讨蛋白激酶CK2β在食管癌组织中的表达及其临床意义。方法选取2010年2月至2013年1月经手术病理证实的原发性食管癌患者58例,采用免疫组织化学法分别检测食管癌及癌旁正常食管黏膜组织芯片中CK2β的表达水平。结果 CK2β在食管癌组织细胞中的细胞核和细胞浆均有表达,呈黄色或棕褐色颗粒状分布。其中,58例食管癌组织有3例(5.2%)阴性,2例(3.5%)弱阳性,6例(10.3%)中阳性,47例(81.0%)强阳性;CK2β在食管癌旁正常黏膜组织中多呈阴性表达,仅有3例(5.2%)呈弱阳性。两者阳性表达率差异有统计学意义(P<0.01)。结论蛋白激酶CK2β在食管癌组织中呈明显高阳性表达,可以作为食管癌早期诊断和治疗的敏感性及特异性指标,具有重要的临床应用及研究意义。
Objective To investigate the expression of protein kinase CK2β in esophageal cancer and its clinical significance. Methods From January 2010 to January 2013, 58 cases of primary esophageal carcinoma confirmed by operation and pathology were selected. Immunohistochemistry was used to detect the expression of CK2β in esophageal cancer and normal tissue adjacent to the esophageal mucosa. Results CK2β was expressed in both nucleus and cytoplasm of esophageal cancer tissue cells, showing a yellow or tan granule distribution. Of these, 58 cases of esophageal cancer were negative (5.2%), 2 cases (3.5%) were weakly positive, 6 cases (10.3%) were positive, and 47 cases (81.0%) were strongly positive; CK2beta was normal mucosa around esophageal cancer. Most of the tissues were negative and only 3 (5.2%) were weakly positive. The difference in positive expression rate between the two groups was statistically significant (P<0.01). Conclusion Protein kinase CK2β is highly expressed in esophageal cancer tissues. It can be used as a sensitive and specific indicator for the early diagnosis and treatment of esophageal cancer. It has important clinical application and significance.