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目的：通过研究正常妊娠及患妊娠高血压综合征（妊高征）时，胎盘绒毛中超氧化物歧化酶（ＳＯＤ）与脂质过氧化物（ＬＰＯ）含量变化，探讨妊高征发病机理。方法：采用放射免疫法和改良八木国夫法，对１１０例正常孕妇及８例妊高征患者进行胎盘绒毛组织ＳＯＤ１和ＬＰＯ含量测定。统计采用ｔ检验、直线相关和回归分析。结果：妊高征组胎盘绒毛ＳＯＤ１含量虽高于正常组，但差异无显著性（Ｐ＞０．０５）；ＬＰＯ含量则明显高于正常组（Ｐ＜０．００５）。正常妊娠时，胎盘绒毛ＳＯＤ１、ＬＰＯ含量均随孕周增加而增高（Ｐ＜０．００１），ＳＯＤ１与ＬＰＯ含量密切相关（Ｐ＜０．００５）。结论：妊高征与胎盘绒毛ＬＰＯ增高有一定关系。
Objective: To study the pathogenesis of pregnancy induced hypertension (PIH) by studying the changes of superoxide dismutase (SOD) and lipid peroxidation (LPO) in placenta during normal pregnancy and pregnancy induced hypertension (PIH). Methods: Radioimmunoassay and modified Yagi Kokushe method, 110 cases of normal pregnant women and 8 cases of pregnancy induced hypertension in placental tissue SOD 1 and LPO levels were determined. Statistics using t test, linear correlation and regression analysis. Results: The content of SOD1 in placenta of PIH was higher than that of normal group, but the difference was not significant (P> 0.05). The content of LPO was significantly higher than that of normal group (P <0.005). In normal pregnancy, the content of SOD1 and LPO in placenta increased with gestational weeks increasing (P <0.001), while SOD1 was closely related with LPO content (P <0.005). Conclusion: There is a certain relationship between PIH and placental LPO increase.