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目的探讨T2DM患者血清富含半胱氨酸酸性分泌蛋白(SPARC)与颈动脉粥样斑块的相关性。方法收集T2DM+颈动脉斑块组(T2DM+CP)、单纯T2DM组(T2DM)及正常对照组(NGT),采用ELISA检测血清SPARC水平。结果 T2DM+CP组、T2DM组血清SPARC水平高于NGT组[(17.44±2.64)vs(14.67±2.30)vs(12.09±2.78)g/L],T2DM+CP组高于T2DM组(P<0.05或P<0.01)。相关分析显示,血清SPARC水平与TG、BMI、高敏C反应蛋白(hsC-RP)、FPG、HOMAIR呈正相关,与HDL-C呈负相关(P<0.05)。多元线性逐步回归分析表明,TG是血清SPARC水平的独立影响因素(β=0.414,P<0.01)。结论 SPARC可能与T2DM及其颈动脉粥样斑块的发生发展相关。
Objective To investigate the correlation between serum cysteine-rich acidic secreted protein (SPARC) and carotid plaque in T2DM patients. Methods T2DM + carotid plaque group (T2DM + CP), T2DM group (T2DM) and normal control group (NGT) were collected. Serum levels of SPARC were measured by ELISA. Results The levels of SPARC in T2DM + CP group and T2DM group were significantly higher than those in NGT group [(17.44 ± 2.64) vs (14.67 ± 2.30) vs (12.09 ± 2.78) g / L] Or P <0.01). Correlation analysis showed that serum SPARC level was positively correlated with TG, BMI, hsC-RP, FPG and HOMAIR, but negatively correlated with HDL-C (P <0.05). Multiple linear stepwise regression analysis showed that TG was an independent factor of serum SPARC level (β = 0.414, P <0.01). Conclusion SPARC may be related to the development of T2DM and its carotid atherosclerotic plaque.