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聚己内酯-聚赖氨酸嵌段共聚物(PCL-b-PLys)在水中自组装形成了聚赖氨酸为壳和聚己内酯为核的球形胶束.以胶束为模板,利用聚赖氨酸的胺基与金的配位作用,引导金在胶束壳层上生长,形成了胶束-金壳纳米结构(micelle@gold nanoshell).用紫外可见光谱、X射线光电子能谱、广角X射线衍射、透射电镜、动态光散射、热重分析、光热转化实验、以及体外光热杀死癌细胞实验等对金壳结构进行了结构确认和性能表征.胶束-金壳结构比原胶束增大约30%～40%,金约占总重量2/3.而且,其具有很强的近红外吸收性能和高达63%的近红外光-热转化效率.近红外激光照射10 min,可杀死约60%的宫颈癌细胞,且自身的细胞毒性低.
Polycaprolactone-polylysine block copolymer (PCL-b-PLys) self-assembled in water to form a polylysine shell and polycaprolactone as the core of the spherical micelles.Using micelles as a template, The coordination of the amino groups of polylysine with gold led to the growth of micelles on the micellar shell, forming micelle @ gold nanoshell. UV-visible spectra, X-ray photoelectron energy The structure and structure of the gold shell were characterized by X-ray diffraction, transmission electron microscopy, transmission electron microscopy, dynamic light scattering, thermogravimetric analysis, photothermal conversion experiments and in vitro photothermal to kill cancer cells. The structure is about 30% ~ 40% more than the original micelles, and the gold accounts for about 2/3 of the total weight. Moreover, it has strong near-infrared absorption and up to 63% near-infrared light-thermal conversion efficiency. 10 min, can kill about 60% of cervical cancer cells, and its own low cytotoxicity.