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目的探讨抗 C 反应蛋白单体(mCRP)抗体在系统性红斑狼疮(SLE)中的意义。方法以天然的 mCRP 为抗原,用 ELISA 的方法检测113例 SLE 患者、疾病对照组(65例,包括类风湿关节炎、原发性干燥综合征、骨关节炎、强直性脊柱炎、系统性硬化症、混合结缔组织病)和正常对照组(32例)血清抗 mCRP 抗体水平,同时检测 SLE 患者血清 CRP 水平,记录其各种临床表现及实验室指标,分析抗 mCRP 抗体与 CRP 水平及疾病活动性的关系。结果 SLE 患者的抗 mCRP 抗体水平显著高于疾病对照组和正常对照组(t=2.502,5.352,P 均<0.05)。抗 mCRP 抗体阳性的 SLE 患者的红细胞沉降率(ESR)较抗 mCRP 抗体阴性患者明显增快(t=2.869,P<0.01),但两者的外周血 CRP 水平相似(H=-0.432,P>0.05)。SLE 患者抗 mCRP 抗体水平与 SLE 疾病活动指数的高低及血清 IgG水平的高低呈明显的正相关(r=0.248,0.392,P 均<0.01),与合并感染无明显相关性(t=0.658,P>0.05)。结论 SLE 患者血清抗 mCRP 抗体水平明显增高,并与患者的 SLE 疾病活动指数的高低呈明显的正相关;抗 mCRP 抗体可作为判断 SLE 疾病活动性的指标之一。
Objective To investigate the significance of anti-C reactive protein (mCRP) antibody in systemic lupus erythematosus (SLE). Methods Using natural mCRP as antigen, 113 patients with SLE were tested by ELISA. The disease control group (65 cases, including rheumatoid arthritis, Sjogren’s syndrome, osteoarthritis, ankylosing spondylitis, systemic sclerosis , Mixed connective tissue disease) and normal control group (32 cases). Meanwhile, serum CRP levels in SLE patients were also measured. Various clinical manifestations and laboratory indexes were recorded, and anti-mCRP antibody and CRP levels and disease activity were analyzed Sexual relations. Results The level of anti-mCRP antibody in patients with SLE was significantly higher than that in the control group and the normal control group (t = 2.502, 5.352, P <0.05). The erythrocyte sedimentation rate (ESR) of anti-mCRP antibody-positive SLE patients was significantly higher than that of anti-mCRP antibody negative patients (t = 2.869, P <0.01) 0.05). The level of anti-mCRP antibody in patients with SLE was positively correlated with the activity index of SLE disease and the level of serum IgG (r = 0.248,0.392, P <0.01), but not with the co-infection (t = 0.658, P > 0.05). Conclusion The level of anti-mCRP antibody in patients with SLE is significantly higher than that in patients with SLE. The anti-mCRP antibody may be used as one of the indicators of SLE disease activity.