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目的探讨检测突发性感音神经性耳聋(SSHL)患者血清一氧化氮(NO)与C反应蛋白(CRP)的意义。方法全部患者采用活血素加东菱克栓酶加皮质类固醇激素治疗1个疗程(10~15 d)后第2天复查听力。用免疫透射比浊法测定CRP含量,采用硝酸还原酶法测定内皮NO释放水平。结果突聋组血清NO含量明显降低,CRP含量明显升高,与对照组比较均有显著性差异(P<0.01)。突聋组治疗后NO显著回升(P<0.05)、CRP显著下降(P<0.05)。治疗有效者与无效者血清NO、CRP含量比较也有统计学差异(P<0.05)。结论在SSHL发作过程中,检测患者NO、CRP含量的变化对疾病的诊断及疗效的观察具有重要意义。
Objective To explore the significance of detecting serum nitric oxide (NO) and C-reactive protein (CRP) in patients with sudden sensorineural hearing loss (SSHL). Methods All patients were treated with hematin plus batroxobin and corticosteroids for one course of treatment (10-15 days) and then the hearing was reviewed on the second day. The content of CRP was determined by immunoturbidimetry, and the NO release level was determined by nitrate reductase method. Results The serum NO level in patients with sudden deafness decreased significantly and the content of CRP increased significantly compared with the control group (P <0.01). After treatment, NO significantly increased (P <0.05) and CRP decreased significantly (P <0.05). There was also a significant difference in the levels of serum NO and CRP between the effective and non-effective persons (P <0.05). Conclusions During the course of SSHL, detecting the changes of NO and CRP levels in patients is of great significance for the diagnosis and treatment of diseases.