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以6mg/kg体重皮下注射N-亚硝基-N-氨基甲酸乙酯诱发大鼠急性肺泡损伤,在注射后第2天,肺泡灌洗液(即肺泡空间成份)表面活性物质磷脂含量明显减少,而蛋白质含量明显增加。细胞内层状体和微粒体中磷脂及蛋白质含量未见明显改变。与此同时,各肺成份中磷脂的组成也发生了变化,即PG/PI的比率明显降低。分子种的检测显示,两种酸性磷脂(Po和PI)的分子种构成不同,其主要分子种在急性肺泡损伤时有所改变。
Acute alveolar damage was induced in rats by subcutaneous injection of N-nitroso-N-methylcarbamate (6 mg / kg body weight). On the second day after injection, the phospholipid content of surfactant in alveolar lavage fluid (alveolar space component) , While the protein content increased significantly. No significant changes in phospholipid and protein content in laminar and microsomal cells. At the same time, the composition of phospholipids in each lung component also changed, ie the PG / PI ratio was significantly reduced. Molecular species testing revealed that the molecular species of the two acidic phospholipids (Po and PI) varied in composition and that the major molecular species changed during acute alveolar damage.