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氟是人体必需的微量元素,摄入过多或不足均会引起疾病。氟和其他卤族元素一样能透过血脑屏障,而脑组织内的氟也能南脑脊液的引流排泄作用排出脑外,并维持脑内氟的相对平衡。但人体如果长期摄入高氟,则过量的氟将潴留在脑内,进而影响脑细胞正常的生理功能。1937年Shoutt首先报道了地方性氟
Fluorine is an essential trace element of the human body, excessive intake or deficiency can cause disease. Fluorine, like other halogen elements, penetrates the blood-brain barrier. Fluorine in brain tissue also exudes from the brain through drainage and drainage of the southern cerebrospinal fluid and maintains the relative balance of fluorine in the brain. However, if the body long-term intake of high fluoride, the excess fluoride will remain in the brain, thereby affecting the normal physiological function of brain cells. Shoutt first reported on 1937 local fluoride