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目的探讨血清C反应蛋白(CRP)、白细胞介素-18(IL-18)、抵抗素和外周血白细胞(WBC)与代谢综合征(MS)的关系。方法通过检测158例MS患者和160例一般情况匹配的非MS者的血清CRP、IL-18、抵抗素、WBC、血脂、体重指数(BMI)、胰岛素抵抗指数等指标,比较两组人群血清CRP、IL-18、抵抗素和WBC的差异,分析其与胰岛素抵抗(IR)的关系。结果 MS者血清CRP、IL-18、抵抗素水平高于非MS人群,差异有统计学意义(P<0.05);MS者外周血WBC水平高于非MS人群,但差异无统计学意义(P>0.05);回归分析结果示:血清CRP、IL-18、抵抗素和WBC都是IR的独立影响因素。结论 MS者血清CRP、IL-18水平和抵抗素高于非MS人群。提示,慢性炎症反应可能是MS的病因之一。
Objective To investigate the relationship between serum C-reactive protein (CRP), interleukin-18 (IL-18), resistin and peripheral blood leukocytes (WBC) and metabolic syndrome (MS) Methods The serum levels of CRP, IL-18, resistin, WBC, lipids, body mass index (BMI) and insulin resistance index in 158 patients with MS and 160 normal non- , IL-18, resistin and WBC, and analyze its relationship with insulin resistance (IR). Results The levels of serum CRP, IL-18 and resistin in MS patients were significantly higher than those in non-MS patients (P <0.05). The levels of peripheral blood WBC in MS patients were higher than those in non-MS patients, but the difference was not statistically significant > 0.05). The results of regression analysis showed that serum CRP, IL-18, resistin and WBC were independent factors of IR. Conclusion MS serum CRP, IL-18 levels and resistin than non-MS population. Tip, chronic inflammatory reaction may be one of the causes of MS.