一向认为,红细胞生成素(EPO)的主要作用是通过与造血前体细胞表面的EPO受体(EPO re-ceptor,EPOR)结合,调节红系祖细胞增殖、成熟、分化,因而广泛用于各种贫血治疗和围手术期减少术中、术后异体输血。近年来,随着体内多种器官和组织(脑、子宫、睾丸等)EPO和(或)EPOR的发现,EPO的 It has been thought that erythropoietin (EPO) plays a major role in regulating the proliferation, maturation and differentiation of erythroid progenitor cells by binding to the EPO receptor (EPO receptor) on the surface of hematopoietic progenitor cells and is therefore widely used Anemia treatment and perioperative reduction of intraoperative and postoperative allogeneic blood transfusion. In recent years, with the discovery of EPO and / or EPOR of various organs and tissues in the body (brain, uterus, testes, etc.), EPO