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在最早的15例宽—β疾病患者中,极低密度脂蛋白(VLDL)的主要蛋白物成份脱辅基脂蛋白E有不同的焦点模式(脱辅基蛋白E—D)。为了分析脱辅基脂蛋白E的表现型,已发展了一种不用超速离心机的方法,应用此法并与常规标准对照,证明: 1.脱辅基脂蛋白E显示出一种遗传决定的多态性。其三种表现型为脱辅基脂蛋白E—N、脱辅基脂蛋白E—ND和脱辅基脂蛋白E—D是由两个等位基因脱辅基脂蛋白E~w(～0.91)和脱辅基脱蛋白E~d(～0.09)决定的。
In the first 15 patients with broad-beta disease, apolipoprotein E, the major protein component of very low density lipoprotein (VLDL), had a different focal mode (apoprotein E-D). In order to analyze the phenotype of apolipoprotein E, a method without an ultracentrifuge has been developed, using this method and in comparison with conventional standards, demonstrating that: 1. Apolipoprotein E shows a genetically determined Polymorphism. The three phenotypes are apolipoprotein E-N, apolipoprotein E-ND and apolipoprotein E-D, which are composed of two alleles of apolipoprotein E ~ w (-0.91 ) And apo-deproteinized E ~ d (~ 0.09).