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目的探讨溴吡斯的明致老年患者严重缓慢性心律失常的机制和临床特点。方法通过回顾性分析8例服用溴吡斯的明引起严重缓慢性心律失常的患者,采用测量血压及行十二导联心电图/24h动态心电图检查。结果使用溴吡斯的明后出现严重缓慢性心律失常表现,经予药物(阿托品、654-2、异丙肾上腺素),紧急临时心脏起搏治疗后,心律失常得以纠正。结论对病程长、身体差的老年重症肌无力患者,使用溴吡斯的明治疗时要掌握好剂量,随访心电图,警惕用药后导致缓慢心律失常,造成严重后果。
Objective To investigate the mechanism and clinical features of triptolide-induced elderly patients with severe bradyarrhythmia. Methods A retrospective analysis of 8 patients taking bromopyrazine in patients with severe bradyarrhythmia was performed by measuring blood pressure and 12-lead electrocardiogram / 24h ambulatory electrocardiogram. Results The use of triptolide showed severe delayed arrhythmia after the onset of acute arrhythmia after medication (atropine, 654-2, isoproterenol) and emergency temporary cardiac pacing. Conclusion For elderly patients with myasthenia gravis who have long course and poor body, we should master the dose when using tribromide, and follow-up electrocardiogram (ECG), and vigilance will lead to slow arrhythmia after administration, which will cause serious consequences.