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目的 探讨纳络酮对脑梗死患者血浆神经肽Y(NPY)、β 内啡肽 (β EP)含量的影响及其促抑郁的作用。方法 采用放免法测定 70例不伴抑郁症的脑梗死患者治疗前后血浆NPY、β EP水平并评定治疗后抑郁症的发病情况。结果 纳络酮治疗组发生抑郁 11例 ,常规治疗组发生抑郁 3例。纳络酮组治疗后的血浆NPY及 β EP水平低于对照组 (P <0 .0 1)。 结论 纳络酮能改变血浆NPY、β EP水平 ,有促抑郁作用
Objective To investigate the effects of naloxone on the levels of plasma neuropeptide Y (NPY) and β-endorphin (β EP) in patients with cerebral infarction and its role in promoting depression. Methods The plasma levels of NPY and β EP in 70 patients with cerebral infarction without depression were measured by radioimmunoassay and the incidence of depression after treatment was assessed. Results Naloxone treatment group had depression in 11 cases, and conventional treatment group had depression in 3 cases. The levels of plasma NPY and β EP in naloxone group were lower than those in control group (P <0.01). Conclusion Naloxone can change the levels of plasma NPY and β EP, and promote depression