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目的观察埃索美拉唑联合莫沙必利治疗反流性食管炎的临床疗效。方法将反流性食管炎患者96例随机分为试验组、对照A组及对照B组各32例。试验组给予埃索美拉唑联合莫沙必利治疗,对照A组和B组患者分别给予埃索美拉唑和莫沙必利治疗,3组患者均连续给药5周。停药后观察3组临床症状治疗情况及食管炎治愈情况。结果试验组总有效率和食管炎总治愈率均高于对照A组和对照B组,差异均有统计学意义(P<0.05)。结论埃索美拉唑联合莫沙必利治疗反流性食管炎能显著提高临床总有效率及总治愈率,在临床上具有重要意义。
Objective To observe the clinical efficacy of esomeprazole combined with mosapride in the treatment of reflux esophagitis. Methods 96 patients with reflux esophagitis were randomly divided into experimental group, control group A and control group B, 32 cases each. The trial group was given esomeprazole combined with mosapride, and the patients in control group A and group B were treated with esomeprazole and mosapride, respectively. All three groups were given continuous treatment for 5 weeks. After stopping the treatment of three groups observed clinical symptoms and esophagitis cure. Results The total effective rate and the total cure rate of esophagitis in experimental group were higher than those in control group A and control group B, the difference was statistically significant (P <0.05). Conclusion Esomeprazole combined with mosapride in the treatment of reflux esophagitis can significantly improve the total effective rate and the total cure rate, which is of clinical importance.