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出血性休克与脑病综合征是一种以急性起病的脑病、发热、休克、腹泻、严重的弥漫性血管内凝血和肝肾功能障碍为临床表现的疾病,病情进展快,病死率高,预后差.目前该病的病因不明,多认为与感染、高热、细胞因子风暴及遗传相关.诊断主要是依靠某些特定临床症状的组合并排除其他疾病,缺乏特异性诊断标志物.治疗方式主要是补液、降颅压和对症支持等综合治疗.提高对本病认识,早期甄别,早期干预,可望提高疗效,降低病死率和后遗症率.“,”Hemorrhagic shock and encephalopathy syndrome (HSES) is an acute-onset disease whose clinical manifestations are fever,shock,diarrhea,severe disseminated intravascular coagulation and liver and kidney dysfunction,with rapid progression,poor prognosis and high mortality rate.At present,the etiology of HSES is unknown,and it is widely believed that the pathogenesis of HSES is related to infection,high fever,cytokine storm and genetics.There is lack of specific diagnostic markers for the diagnosis of HSES,which mainly depends on some specific clinical features and the exclusion of other diseases.All patients are provided given fluid therapy,intracranial pressure reduction and supportive treatments.It is essential to improve the recognition of HSES,and early diagnosis and early intervention may improve efficacy,and reduce mortality rate and disability rate.