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目的:观察双环醇片和多烯磷酯酰胆碱胶囊治疗甲亢性肝损伤临床疗效和安全性。方法:112例甲亢性肝损伤患者随机分为两组,在常规使用甲巯咪唑治疗同时,观察组56例加用双环醇片,对照组56例加用多烯磷酯酰胆碱胶囊,疗程均为4周。比较两组患者治疗前后丙氨酸转氨酶(ALT)、血清天冬氨酸转氨酶(AST)、总胆红素(TBIL)、碱性磷酸酶(ALP)等指标的变化,观察两组疗效与药品不良反应。结果:治疗后两组ALT、AST、TBIL、ALP水平均较治疗前显著下降(P<0.05),且观察组ALT、AST水平明显低于对照组(P<0.05),而TBIL、ALP水平无差异(P>0.05)。观察组总有效率明显高于对照组(P<0.05)。两组药品不良反应均较轻微。结论:双环醇片能有效治疗甲亢性肝损伤,且疗效优于多烯磷酯酰胆碱。
Objective: To observe the clinical efficacy and safety of bicyclic alcohol tablets and polyene phosphatidylcholine capsules in the treatment of hyperthyroidism liver injury. Methods: One hundred and twelve cases of hyperthyroidism liver injury were randomly divided into two groups. In the routine use of methimazole treatment, 56 cases were treated with bicyclol tablets in the observation group and 56 cases in the control group were treated with polyene phosphatidylcholine capsules. The treatment course All for 4 weeks. The changes of ALT, AST, TBIL and ALP before and after treatment were compared between the two groups. The curative effect and drugs Adverse reactions. Results: After treatment, the levels of ALT, AST, TBIL and ALP in both groups decreased significantly (P <0.05), and the levels of ALT and AST in the observation group were significantly lower than those in the control group (P <0.05), while the levels of TBIL and ALP Difference (P> 0.05). The total effective rate in observation group was significantly higher than that in control group (P <0.05). Two groups of adverse drug reactions are minor. CONCLUSION: Bicycloalcoholic tablets can effectively treat hyperthyroidism liver injury and its efficacy is better than that of polyene phosphatidylcholine.