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2-(取代苯乙烯基)-4-氨基吡啶类化合物(Ⅰ)对感染伯氏鼠疟原虫的小鼠具有较好的治疗作用~[1]。为了提高这类化合物的抗疟作用并延长其作用时间,我们模拟长效抗疟药喹哌(Ⅱ)的结构特点,合成了双分子化合物——1,3-双[4-[2-(取代苯乙烯基)吡啶基-4-哌嗪基-1-]丙烷(Ⅲ)。
2- (Substituted styryl) -4-aminopyridine compounds (Ⅰ) in mice infected with P. murine parasite has a better therapeutic effect ~ [1]. In order to improve the antimalarial activity of these compounds and to prolong their duration of action, we simulated the structural characteristics of long-acting antimalarial drug quipira (Ⅱ) and synthesized a bimolecular compound, 1,3-bis [4- [2- Substituted styryl) pyridyl-4-piperazinyl-1-] propane (III).