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目的观察T2DM合并乙型肝炎肝硬化(HBLC)患者不同HbA1c水平的血清细胞因子的变化。方法选取T2DM合并HBLC患者65例,根据HbA1c水平分为血糖控制良好组及血糖控制欠佳组,检测两组血清IL-2、IL-4、IL-6、IL-8、IL-10、干扰素γ(INF-γ)及TNF-α水平。结果血糖控制良好组血清细胞因子IL-2、TNF-α[(42.7±20.5)pg/ml、(30.5±20.2)ng/ml]低于血糖控制欠佳组[(58.2±23.8)pg/ml、(43.5±33.7)ng/ml],血糖控制良好组IL-4、IL-6、IL-8水平[(3.2±1.1)、(7.1±3.7)、(58.3±50.8)pg/ml]高于血糖控制欠佳组[(1.1±0.5)、(3.0±1.3)、(35.5±17.6)pg/ml,P<0.05]。血清IL-8、INF-γ水平两组间差异无统计学意义(P>0.05)。结论 T2DM合并HBLC患者血糖控制良好组对比血糖控制欠佳组辅助性T细胞1和2(Th1/Th2)细胞因子差异明显,其意义有待进一步探究。
Objective To observe the changes of serum cytokines with different levels of HbA1c in T2DM patients with hepatitis B cirrhosis (HBLC). Methods Totally 65 patients with T2DM and HBLC were divided into two groups according to the level of HbA1c: blood glucose control group and blood glucose control group. The levels of IL-2, IL-4, IL-6, IL- Su-γ (INF-γ) and TNF-α levels. Results Serum levels of IL-2 and TNF-α [(42.7 ± 20.5) pg / ml, (30.5 ± 20.2) ng / ml] were significantly lower in patients with good glycemic control than in those with poor glycemic control [(58.2 ± 23.8) pg / ml , (43.5 ± 33.7) ng / ml, respectively]. The levels of IL-4, IL-6 and IL-8 in the blood glucose control group were significantly higher than those in the control group [(3.2 ± 1.1), (7.1 ± 3.7), (58.3 ± 50.8) pg / (1.1 ± 0.5), (3.0 ± 1.3), (35.5 ± 17.6) pg / ml, P <0.05]. Serum IL-8, INF-γ levels between the two groups showed no significant difference (P> 0.05). Conclusion There are significant differences in the levels of Th1 / Th2 cytokines in T2DM patients with well-controlled blood glucose control and those with poor blood glucose control. The significance of this study remains to be further explored.