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作者检查了30例SLE患者周围血的染色体,其中26例有染色体畸变,表现为裂隙、断裂、微小体、碎片和多倍体,总的细胞畸变率为4.13％,显著高于对照组畸变率(0.8％)(P<0.01),显示患者染色体脆性增加易断。畸变与临床表现及化验检查无明显关联。染色体脆性增加与癌肿发病之间存在着有一定的关系,两者是染色体不稳定综合征的主要表现。本组有2例伴有癌肿,一例为甲状腺癌,一例为胆囊癌。因此,作者认为SLE也是一种染色体不稳定综合征。
The authors examined the chromosomes of the peripheral blood of 30 patients with SLE, of which 26 had chromosomal aberrations that showed fissures, ruptures, microsomes, debris and polyploidy with a total cellular aberration rate of 4.13%, significantly higher than the control group (0.8%) (P <0.01), showing that patients with chromosomal fragility increased easily broken. Distortion and clinical manifestations and laboratory tests no significant correlation. There is a relationship between the increase of chromosomal fragility and the incidence of cancer, both of which are the main manifestations of chromosome instability syndrome. This group has 2 cases with cancer, one case of thyroid cancer, a case of gallbladder cancer. Therefore, the authors believe that SLE is also a chromosomal instability syndrome.