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本文对N-(对-硝基)苄基-1,7,7-三甲基-双环[2.2.1]庚烷-2-亚胺(3)和N-[11—[12-羟基-12-二苯基]甲基]苄基-1,7,7-三甲基-双环[2.2.1]庚烷-2-亚胺(4)进行了X-射线晶体结构分析。采用MOPAC程序的MNDO方法对(+)-樟脑缩苄胺即N-苄基-1,7,7-三甲基-双环[2.2.1]庚烷-2-亚胺(2a)的内部转动势能进行了理论计算。结果表明,(+)-樟脑缩苄胺(2a)以反式(trans)构象形式存在,它在不对称反应中的立体选择性主要受樟脑环上方C10甲基的控制。
In this paper, the synthesis of N- (p-nitro) benzyl-1,7,7-trimethyl-bicyclo [2.2.1] 12-diphenyl] methyl] benzyl-1,7,7-trimethyl-bicyclo [2.2.1] heptan-2-imine (4) was subjected to X-ray crystallographic analysis. The internal rotation of (+) - camphylbenzylamine, N-benzyl-1,7,7-trimethyl-bicyclo [2.2.1] heptan-2-imine (2a), using the MOPAC procedure for MNDO Potential energy has been calculated theoretically. The results showed that the (+) - camphrin (2a) existed in trans conformation and its stereoselectivity in the asymmetric reaction was mainly controlled by the C10 methyl group on the camphor ring.