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目的探讨极低出生体重儿呼吸道分泌物解脲脲原体(UU)阳性与肺部损伤的关系。方法选择2011年10月至2013年5月我院新生儿重症监护病房收治的极低出生体重儿,采用荧光定量聚合酶链反应法检测入院时呼吸道分泌物UU核酸,根据检测结果分为阳性组和阴性组。比较两组入院时感染标记物、新生儿呼吸窘迫综合征、先天性肺炎发生率的差异,以及住院时间28天以上者支气管肺发育不良发生率。结果 174例极低出生体重儿中,UU阳性69例,阴性105例;UU阳性组新生儿呼吸窘迫综合征发生率(26.1%,18/69)低于阴性组(56.2%,59/105);先天性肺炎发生率(47.8%,33/69)高于阴性组(31.4%,33/105);住院28天以上的VLBWI 145例,其中UU阳性56例,阴性89例,两组支气管肺发育不良发生率差异无统计学意义。而对于体重<1250 g的极低出生体重儿,UU阳性组支气管肺发育不良发生率(74.1%,20/27)高于阴性组(45.0%,18/40)。结论呼吸道分泌物UU阳性增加了极低出生体重儿先天性肺炎、出生体重<1250 g的极低出生体重儿支气管肺发育不良的发生风险,是新生儿呼吸窘迫综合征的保护性因素。
Objective To investigate the relationship between positive ureaplasma urealyticum (UU) and lung injury in very low birth weight infants. Methods Ultra-low birth weight children admitted to neonatal intensive care unit in our hospital from October 2011 to May 2013 were enrolled in this study. Fluorescent quantitative polymerase chain reaction (PCR) was used to detect UU nucleic acid of respiratory secretions on admission. According to the results, the patients were divided into positive group And negative group. Differences in the incidence of infectious markers, neonatal respiratory distress syndrome, and congenital pneumonia were compared between the two groups, and the incidence of bronchopulmonary dysplasia for hospital stays longer than 28 days. Results Among the 174 cases with very low birth weight, 69 cases were UU positive and 105 were negative. The incidence of respiratory distress syndrome in neonates with UU positive group was lower than that in negative group (26.1%, 18/69) (56.2%, 59/105) ; Incidence of congenital pneumonia (47.8%, 33/69) was higher than that of negative group (31.4%, 33/105); 145 cases of VLBWI hospitalized more than 28 days, of which 56 were UU positive and 89 were negative, The incidence of dysplasia was no significant difference. For very low birth weight children weighing <1250 g, the prevalence of bronchopulmonary dysplasia in the UU positive group (74.1%, 20/27) was higher than that in the negative group (45.0%, 18/40). Conclusions Positive UU of respiratory secretions increased the risk of congenital pneumonia in very low birth weight infants and the risk of bronchopulmonary dysplasia in very low birth weight infants with birth weight <1250 g, which is a protective factor in neonatal respiratory distress syndrome.