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一日龄小鸡,分别接受不同浓度的回避性刺激物邻氨基苯甲酸甲酯(MeA)训练,间隔一定时间后测试记忆保持。主要结果为:5%和20%MeA训练,分别使动物记忆保持15分钟和50分钟左右,相当于记忆形成多阶段模型中的STM和ITM阶段。40%MeA训练,记忆保持到训练后8-10小时,相当于不依赖新糖蛋白合成的LTM形成的早期阶段。只有60%以上浓度的MeA训练才使记忆保持至少24小时。上述结果提示,利用弱化训练的方法,不仅可以将STM,ITM和LTM分离开,而且可把LTM形成的早期阶段分离出来独立研究,增加了对LTM新的理解,为进一步探讨记忆形成机制提供了一条新的途径。
One-day-old chickens were trained on different concentrations of avoidant stimulant methyl anthranilate (MeA) and tested for memory retention at intervals. The main results were: 5% and 20% MeA training, keeping animal memory for 15 and 50 minutes, respectively, equivalent to the STM and ITM phases in the multiphase model of memory formation. 40% MeA training, memory is maintained until 8-10 hours after training, equivalent to the early stages of LTM formation independent of neoglycoprotein synthesis. Only MeA training at concentrations greater than 60% will keep the memory for at least 24 hours. The above results suggest that using the method of weakening training can not only separate the STM, ITM and LTM, but also separate the early stages of LTM formation, gain new understanding of LTM and provide a new way to further explore the mechanism of memory formation A new way.