一氧化氮(NO)是一种重要的血管活性因子,通过激活平滑肌细胞内鸟苷酸环化酶而产生血管舒张作用,它还参与高血压、动脉粥样硬化及冠心病等心血管疾病的病理机制,与NO的前体左旋精氨酸(LArg)结构类似的物质如L-N~G-monomethylarginine(L-NMMA)能够选择性地抑制NO合成酶,减少NO的生成,从而对心血管系统产生一系列的影响。L-N~G-nitro-arginine(L-NNA)也是L-Arg的衍生物,关于它对脑血管、冠状动脉的作用已有报道。本文研究的是它对大鼠、豚鼠离体主动脉的作用。 Nitric oxide (NO) is an important vasoactive factor that produces vasodilatation by activating guanylate cyclase in smooth muscle cells. It is also involved in cardiovascular diseases such as hypertension, atherosclerosis and coronary heart disease Pathological mechanism, NO-like precursor L-arginine (LArg) structurally similar substances such as LN ~ G-monomethylarginine (L-NMMA) can selectively inhibit NO synthase and reduce the NO generation, resulting in the cardiovascular system A series of effects. L-N ~ G-nitro-arginine (L-NNA) is also a derivative of L-Arg, and its role in cerebrovascular and coronary arteries has been reported. This article studies its effect on isolated aortas in rats and guinea pigs.