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本工作旨在观察血管升压素（ＡＶＰ）对大鼠主动脉弓压力感受器活动的影响。全部实验是在隔离灌流的大鼠主动脉弓──主动脉神经标本上进行的。在２５例标本，所得结果如下：（１）主动脉弓内压（ＩＡＰ）在１３．３ｋＰａ条件下，ＡＶＰ（１０－８ｍｏｌ／Ｌ）使主动脉神经传入放电积分（ＭＮＡ）较对照增加４０±４．７％（Ｐ＜０．０００１）；升降ＩＡＰ时，ＩＡＮＡ随之增减，ＩＡＮＡ－ＩＡＰ关系曲线与对照相比向左上方移位，曲线最大积分值（ＰＩＶ）由６２１±８５增加至７１１±８１％·ｋＰａ－１（Ｐ＜０．０１），但阈压（ＴＰ），饱和压（ＳＰ），工作范围（ＯＲ）和最大斜率（ＰＳ），均无明显变化（Ｐ＞０．０５）；冲洗掉ＡＶＰ后，主动脉神经传入放电基本恢复对照水平。（２）ＩＡＰ在１３．３ｋＰａ条件下，灌流液中加入Ｖ１受体拮抗剂ｄ（ＣＨ２）５Ｔｙｒ－（Ｍｅ）ＡＶＰ（１０－７ｍｏｌ／Ｌ），８—１０ｍｉｎ后再加入ＡＶＰ（１０－８ｍｏｌ／Ｌ），则ＩＡＮＡ不再变化，压力感受器机能曲线无明显移位。（３）在同一保持压条件下，灌流液中分别加入五个不同浓度的ＡＶＰ（１０－１１－１０－７ｍｏｌ／Ｌ），ＩＡＮＡ分别为对照的１９０％，１６０％，１５０％，１３０％，１?
The purpose of this study was to investigate the effects of vasopressin (AVP) on baroreceptor activity in the aortic arch of rats. All experiments were performed on aortic arch-isolated aortic nerve specimens from isolated perfused rats. In 25 specimens, the results obtained are as follows: (1) Aortic arch internal pressure (IAP) AVP (10-8 mol / L) increased the afferent aortic firing integral number (MNA) by 40 ± 4 at 13.3 kPa .7% (P <0.0001). IANA increased and decreased ascending and descending IAP, IANA-IAP shifted to the upper left compared with the control, and the maximum integral (PIV) increased from 621 ± 85 to 711 ± 81% · kPa-1 (P <0.01), but there was no significant change in the threshold pressure (TP), saturation pressure (SP), working range (OR) and maximum slope ); After flushing AVP, aortic nerve afferent discharge basically restored the control level. (2) IAP added V1 receptor antagonist d (CH2) 5Tyr- (Me) AVP (10-7mol / L) to the perfusate at 13.3kPa, and then added AVP (10-8mol / L), IANA no longer changes, no significant shift in the baroreceptor performance curve. (3) Under the same holding pressure, five different concentrations of AVP (10-11-10-7mol / L) were added to the perfusate respectively. IANA was 190%, 160%, 150%, 130% 1?