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目的探讨沈阳地区转移性骨肿瘤住院患者抗肿瘤药物不良事件发生的特点和规律,为转移性骨肿瘤患者合理应用抗肿瘤药物、减少不良事件的发生提供参考依据。方法收集2004—2014年沈阳地区4家医院的转移性骨肿瘤患者的病历资料,分析患者不良事件发生的一般情况、所涉及的抗肿瘤药物及药物剂型、所涉及的器官或系统分布。结果发生抗肿瘤药物不良事件的例数为8 242例,累计不良事件30 122例次,其中男性占61.64%,女性占38.36%;45~64岁的患者构成比为47.00%,≥45岁患者构成比为74.99%;不良事件构成比最高的药物类别为其他抗肿瘤药物及辅助治疗药,占39.91%;注射剂的比例最大,占95.43%;不良事件最多涉及到的器官或系统是消化系统,占22.63%。结论转移性骨肿瘤患者使用抗肿瘤药物导致不良事件的药物流行病学调查可为临床合理用药、提高患者生存质量提供参考依据。
Objective To investigate the characteristics and rules of adverse events of antineoplastic drugs in hospitalized patients with metastatic bone tumors in Shenyang and to provide reference for rational use of antineoplastic drugs in patients with metastatic bone tumors and to reduce the incidence of adverse events. Methods The medical records of patients with metastatic bone tumors in 4 hospitals in Shenyang from 2004 to 2014 were collected to analyze the general situation of patients’ adverse events, the antineoplastic drugs and drug formulations involved, and the organs or systems involved. Results A total of 8 242 cases of anti-tumor drug adverse events occurred. The cumulative number of adverse events was 30 122 cases, of which 61.64% were male and 38.36% were female. The patients with 45-64 years old had a ratio of 47.00% and ≥45 years Accounting for 74.99% of the total. The categories with the highest ADRs included other anti-tumor drugs and adjuvant therapies, accounting for 39.91% of the total. The largest proportion of injections was injected, accounting for 95.43%. The organs or systems most involved in adverse events were the digestive system, Accounting for 22.63%. Conclusion Epidemiological survey of drug-induced adverse events in patients with metastatic bone cancer may provide a reference for clinical rational use of drugs and improvement of patients’ quality of life.