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目的 研究CD44v6 在非小细胞肺癌的表达及其临床意义。方法 应用链霉菌抗生物素蛋白-过氧化物酶(SP)法染色技术测定65 例非小细胞肺癌细胞标本CD44v6的表达水平,并分析其与病理类型、淋巴结转移、肿瘤大小及临床分期之间的关系。结果 CD44v6 在非小细胞肺癌组织中表达的阳性率为66.2 % ,显著高于癌旁正常组织(7.7% ),且CD44v6 的表达与淋巴结转移及临床分期有关(P<0.05),但与病理类型无关(P> 0.05)。结论 检测CD44v6基因的表达,有可能为判断非小细胞肺癌淋巴结转移、病变的发展以及评估预后提供依据
Objective To study the expression of CD44v6 in non-small cell lung cancer and its clinical significance. Methods The expression of CD44v6 in 65 cases of non-small cell lung cancer was detected by streptavidin-peroxidase (SP) staining and analyzed with pathological type, lymph node metastasis, tumor size and clinical stage Relationship. Results The positive rate of CD44v6 expression in non-small cell lung cancer tissues was 66.2%, which was significantly higher than that in adjacent normal tissues (7.7%). The expression of CD44v6 correlated with lymph node metastasis and clinical stage (P <0.05) Not related (P> 0.05). Conclusion Detecting the expression of CD44v6 may provide the basis for judging the lymph node metastasis, the development of the lesion and evaluating the prognosis of non-small cell lung cancer