论文部分内容阅读
目的：研究重组人生长激素（ｒｈ ＧＨ） 对肝硬化门静脉高压症患者术后肝功能和营养代谢的影响。方法：选择１９９６ 年６ 月至１９９９ 年８ 月收治的３９ 例肝硬化门静脉高压症患者，随机分为ｒｈＧＨ 组（１７） 例和对照组（２２ 例） ，术后７ｄ 内分别每日肌肉注射ｒｈＧＨ ０ ．２ｉｕ／ｋｇ 或安慰剂（ 生理盐水） ，术前和术后１ 、３ 、７ 、１４ 天分别测定体重、营养指标和肝功能。结果：ｒｈ ＧＨ 组表现为正氮平衡，体重、营养指标、肝功能的改善均比对照组明显（ Ｐ ＜ ０ ．０５） 。结论：ｒｈ ＧＨ 可抑制肝硬化门静脉高压症术后的分解代谢，促进蛋白质合成，改善患者的肝功能和营养状况
Objective: To study the effects of recombinant human growth hormone (rh GH) on postoperative liver function and nutritional metabolism in cirrhotic patients with portal hypertension. Methods: Thirty-nine patients with portal hypertension of liver cirrhosis admitted from June 1996 to August 1999 were randomly divided into rhGH group (n = 17) and control group (n = 22). Intravenous rhGH 0. 2iu / kg or placebo (saline). The body weight, nutrition index and liver function were measured preoperatively and 1, 3, 7 and 14 days after operation. Results: The rh-GH group showed positive nitrogen balance, and the improvement of body weight, nutrition index and liver function were more obvious than those of the control group (P <0.05). Conclusion: rh-GH can inhibit postoperative catabolism, promote protein synthesis and improve liver function and nutritional status in cirrhotic patients with portal hypertension