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目的探讨丹红注射液联合低分子肝素(LMWH)治疗慢性阻塞性肺疾病(COPD)的临床疗效。方法选择122例COPD患者随机分为两组:治疗组62例,对照组60例。治疗组予丹红注射液20ml加入5%葡萄糖或0·9%生理盐水250ml静脉滴注,1次/d,疗程14d,1d后联用低分子肝素2500U皮下注射,2次/d共5d。结果治疗组的患者口唇指端、趾端,发绀较对照组明显减轻。动脉血的氧分压(PaO2)升高、二氧化碳分压(PaCO2)降低;血红蛋白(Hb)、红细胞数(RBC)均较对照组减少。结论丹红注射液联合低分子肝素治疗慢性阻塞性肺疾病的继发性红细胞增多症,疗效好、安全、方便,经济。
Objective To investigate the clinical effect of Danhong injection combined with low molecular weight heparin (LMWH) on chronic obstructive pulmonary disease (COPD). Methods A total of 122 patients with COPD were randomly divided into two groups: treatment group (62 cases) and control group (60 cases). The treatment group to Danhong injection 20ml added 5% glucose or 0.9% saline 250ml intravenous infusion, 1 / d, treatment 14d, 1d after low molecular weight heparin 2500U subcutaneous injection, 2 times / d for 5d. Results In the treatment group, the lip end, toe end and cyanosis of the patients in the treatment group were significantly reduced compared with the control group. Arterial blood pressure (PaO2) increased, partial pressure of carbon dioxide (PaCO2) decreased; hemoglobin (Hb), red blood cell count (RBC) decreased compared with the control group. Conclusion Danhong injection combined with low molecular weight heparin in the treatment of secondary polycythemia of chronic obstructive pulmonary disease has good curative effect, safety, convenience and economy.