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〔日〕/植泽芳广…∥YAKUGAKU ZASSHI.-2005,125(11).-875～879葡萄柚果汁(GJ)中含有香柠檬亭(BG)、二羟基香柠檬亭(DHB)等呋喃香豆素(FC)衍生物。FCs与小肠黏膜上皮细胞中的主要药物代谢酶细胞色素P450(CYP3A4)结合,使该酶活性消失,导致相关药物的吸收率迅速增加而引起副作用
〔〕 / Shizawa Fang Guang ... YAKUGAKU ZASSHI.-2005,125 (11).-875 ~ 879 grapefruit juice (GJ) contains bergamot (BG), dihydroxy bergamot (DHB) and other furans Coumarin (FC) derivatives. FCs bind to cytochrome P450 (CYP3A4), a major drug metabolizing enzyme in intestinal mucosal epithelial cells, causing the activity of the enzyme to disappear, leading to a rapid increase in the absorption rate of related drugs and causing side effects.