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目的:探讨氨酚羟考酮片控制中、重度癌症疼痛的镇痛效果及其安全性。方法:中、重度癌症疼痛患者86例随机分为2组,观察组43例给予氨酚羟考酮片口服,1~2片/次,4次/d;对照组43例给予科洛曲片口服,1~2片/次,4次/d。连续给药,比较2组用药24,48,72 h疼痛缓解程度及不良反应。结果:观察组控制中度癌症疼痛患者总有效率为86.9%,控制重度癌症疼痛患者总有效率75.0%,头晕、轻微头痛、嗜睡、胃部不适等不良反应轻,不需特别处理。对照组控制中度癌症疼痛总有效率为83.3%,控制重度癌症疼痛总有效率63.2%,2组控制中度癌症疼痛效果比较差异无统计学意义(P>0.05),观察组控制重度癌症疼痛效果优于对照组(P<0.05)。结论:氨酚羟考酮片控制中、重度癌症疼痛疗效确切,不良反应轻。
Objective: To investigate the analgesic effect and safety of oxycodone tablets in the control of severe and severe cancer pain. Methods: Eighty-six patients with moderate and severe cancer pain were randomly divided into two groups. In the observation group, 43 cases were given orally with 1, 2 or 4 tablets of paracetamol, Oral, 1 to 2 tablets / time, 4 times / d. Continuous administration, compared two groups of medication 24,48,72 h pain relief and adverse reactions. Results: The total effective rate of the control group was 86.9%. The total effective rate was 75.0% in patients with severe cancer pain. The patients with dizziness, slight headache, drowsiness, stomach discomfort and other adverse reactions were light without special treatment. In the control group, the total effective rate of controlling moderate cancer pain was 83.3% and the total effective rate of controlling severe cancer pain was 63.2%. There was no significant difference between the two groups in the control of moderate cancer pain (P> 0.05) The effect is better than the control group (P <0.05). Conclusion: Oxycodone tablets, acetaminophen tablets control, severe cancer pain curative effect, adverse reactions.