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随着对肾上腺髓质素(ADM)生物学特性认识的深入,已发现体内多数组织器官都可以合成并分泌ADM,ADM具有多种生物学效应,并通过其受体与降钙素基因相关肽(CGRP)受体发挥生物学作用。妊娠期胎盘、绒毛膜、蜕膜和羊膜等组织都可以合成并分泌ADM,且发现该激素在正常妊娠以及病理妊娠时如流产、早产、妊娠期高血压疾病、妊娠合并糖尿病、胎儿生长受限中发挥着重要作用。进一步探讨在这些疾病中ADM的确切作用机制及其途径,并从临床与治疗的角度提出新的研究思路。
With the understanding of the biological characteristics of adrenomedullin (ADM), it has been found that most tissues and organs in vivo can synthesize and secrete ADM. ADM has a variety of biological effects, and through its receptor and calcitonin gene-related peptide (CGRP) receptors play a biological role. Pregnancy placenta, chorion, decidua and amnion and other tissues can synthesize and secrete ADM, and found that the hormone in normal pregnancy and pathological pregnancy such as miscarriage, premature birth, pregnancy-induced hypertension, pregnancy with diabetes, fetal growth restriction In playing an important role. To further explore the exact mechanism of action of ADM in these diseases and its ways, and put forward new research ideas from the clinical and therapeutic point of view.