血压水平与心血管事件危险性之间呈对数线性关系,随着血压水平的增高,靶器官的损害及终点事件危险性亦随之增高。积极的降压治疗可有效地降低心血管事件的危险性。循证医学证据表明,小剂量联合应用不同类别降压药物较单用较大剂量一种药物降压效果更好,且不良反应减少。约70%的患者需要联合应用2种或2种以上的降压药物治疗。但并非所有的降压药联用都能增加降压疗效或减少不良反应,相反,一些降压药合用后还会增加不良反应。 There was a logarithmic linear relationship between blood pressure level and risk of cardiovascular events. With the increase of blood pressure level, the risk of target organ damage and end point also increased. Active antihypertensive therapy can effectively reduce the risk of cardiovascular events. Evidence-based medical evidence shows that low-dose combination of different types of antihypertensive drugs than a single larger dose of a drug antihypertensive effect is better, and adverse reactions decreased. About 70% of patients need to be combined with two or more antihypertensive drugs. However, not all antihypertensive drugs can increase antihypertensive efficacy or reduce adverse reactions, on the contrary, some antihypertensive drugs combined with adverse reactions will increase.