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目的探讨辛伐他汀治疗脑血栓患者的临床效果。方法选取2012年3月至2015年3月吴川市济民优抚医院收治的60例脑血栓患者作为研究对象,按随机数字表法将其分为试验组和对照组,各30例。对照组患者给予常规治疗,试验组患者在对照组基础上口服辛伐他汀,比较两组患者的临床疗效、治疗前后血脂水平及颈动脉内中膜厚度(IMT)值。结果试验组患者的总有效率明显高于对照组,差异有统计学意义(P<0.05);治疗5个月后,试验组患者的胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)均明显低于对照组,高密度脂蛋白胆固醇(HDL-C)明显高于对照组,差异均有统计学意义(均P<0.05);治疗后2.5、5个月,试验组患者的颈动脉IMT值均明显低于对照组,差异均有统计学意义(均P<0.05)。结论在常规治疗基础上,加用辛伐他汀辅助治疗脑血栓患者,可明显提高临床疗效,改善血脂水平,降低颈动脉IMT值。
Objective To investigate the clinical effect of simvastatin on patients with cerebral thrombosis. Methods A total of 60 patients with cerebral thrombosis admitted from Jiulong You Fu Fu Hospital of Wuchuan from March 2012 to March 2015 were selected as study subjects and divided into experimental group and control group with 30 cases in each group according to random number table method. The patients in the control group were given routine treatment. The patients in the test group were given simvastatin orally on the basis of the control group. The clinical curative effect, the blood lipid level before and after treatment and the carotid artery intima-media thickness (IMT) were compared between the two groups. Results The total effective rate of the experimental group was significantly higher than that of the control group (P <0.05). After 5 months of treatment, the TC, TG, (LDL-C) were significantly lower than the control group, high-density lipoprotein cholesterol (HDL-C) was significantly higher than the control group, the difference was statistically significant (all P <0.05); 2.5,5 months after treatment , And the carotid IMT values in the test group were significantly lower than those in the control group (all P <0.05). Conclusion On the basis of conventional treatment, the addition of simvastatin adjuvant therapy in patients with cerebral thrombosis, can significantly improve the clinical efficacy, improve blood lipid levels, reduce the carotid artery IMT value.