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用巢式聚合酶链反应(PCR)检测62例白血病及26例非血液系统疾病的对照组患儿骨髓涂片中B_(19)-DNA。结果显示①化疗期间白血病患儿骨髓标本B_(19)-DNA阳性率35.5％,与对照组比较差异非常显著(P<0.01);②B_(19)-DNA阳性的急性与慢性白血病无显著性差异(P>0.05);③急性淋巴细胞白血病化疗期有较高的B_(19)感染率(感染率40.0％),但白血病完全缓解率有轻度上升趋势。提示白血病患儿是B_(19)的易感群体,化疗及免疫功能低下的白血病患儿发生B_(19)感染易引起持续感染致慢性贫血。
Nested polymerase chain reaction (PCR) was used to detect B_ (19) -DNA in bone marrow smears from 62 leukemia patients and 26 non-hematologic patients. The results showed that the positive rate of B 19 gene in the leukemia patients was 35.5% during chemotherapy, which was significantly different from that of the control group (P <0.01); ② There was no significant difference between the B_ (19) -DNA positive acute and chronic leukemia (P0.05) .③The infection rate of B 19 infection rate (40.0%) was high in the chemotherapy of acute lymphoblastic leukemia, but the complete remission rate of leukemia increased slightly. It is suggested that children with leukemia are susceptible to B_ (19). B_ (19) infection in patients with chemotherapy and immunocompromised leukemia is likely to cause persistent infection and chronic anemia.