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在泌尿系统器官慢性疼痛的发病机制中,神经串扰可能是骨盆多器官疼痛和功能变化的基础。YoshiokaK等研究睾丸疼痛模型来验证存在于睾丸疼痛感受器和膀胱反射通路之间的神经串扰可能是膀胱过度活动症的基础这一假说,研究人员将乙酸注射入Wistar大鼠的睾丸后,通过膀胱测压来检测大鼠行为学和膀胱功能的变化,同时检测吲哚美辛和辣椒辣素预处理对其行为学和膀胱功能变化的影响,并且观察大鼠注射乙酸后睾丸和膀胱的重量变化。结果发现大鼠睾丸疼痛行为学的变化和膀胱过度活动症的发生与注射的乙酸浓度相关,
In the pathogenesis of chronic pain in urinary organs, neural crosstalk may be the basis of pain and functional changes in multiple organs of the pelvis. YoshiokaK et al. Studied testicular pain models to test the hypothesis that neural crosstalk, which exists between testis pain receptors and bladder reflex pathways, may be the basis of overactive bladder. The researchers injected acetic acid into the testes of Wistar rats, The changes of behavioral and bladder function in rats were observed. The effects of indometacin and capsaicin pretreatment on the changes of behavior and bladder function were also observed. The weight changes of testis and bladder after acetic acid injection were observed. The results showed that the changes of testicular pain behavior and the occurrence of overactive bladder were related to the injected acetic acid concentration,