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为探讨恶性肿瘤病人放疗前后血清血管内皮生长因子(VEGF)水平变化与预后的相关性,于放疗前后采用双抗体夹心 ELISA 法检测65例恶性肿瘤病人血清 VEGF 的水平,与健康人作对照。结果表明,放疗前肿瘤病人血清 VEGF 水平较对照组明显升高,差异有非常显著意义(P<0.01);放疗结束时及放疗后2～3个月血清 VEGF 水平明显下降(P<0.01)。放疗前和放疗后 NR+PD 组血清 VEGF 水平分别显著高于 CR+PR 组(P<0.01),NR+PD 组放疗后血清 VEGF 水平比放疗前下降,但仍处于高水平状态。放疗后6个月内出现复发或转移的11例中,9例血清 VEGF 含量持续高水平状态,1例放疗后下降了的血清 VEGF 水平再次升高。结论:放疗前血清 VEGF 含量处于低水平状态者,近期疗效好,血清 VEGF 含量处于高水平状态者具有潜在的复发或转移的可能,近期治疗效果不佳。检测血清 VEGF 水平动态变化,可能为恶性肿瘤病人临床分期、病情监测、疗效观察以及预后判断提供新的观察指标。
To investigate the correlation between the changes of serum vascular endothelial growth factor (VEGF) levels and the prognosis of malignant tumor patients before and after radiotherapy, serum VEGF levels in 65 malignant tumor patients were detected by double antibody sandwich ELISA before and after radiotherapy, which was compared with healthy people. The results showed that the level of serum VEGF in patients with tumor before radiotherapy was significantly higher than that in the control group (P <0.01). At the end of radiotherapy and at 2 ~ 3 months after radiotherapy, serum VEGF decreased significantly (P <0.01). Serum VEGF levels in NR + PD group before and after radiotherapy were significantly higher than those in CR + PR group (P <0.01). The level of VEGF in NR + PD group was lower than that before radiotherapy but still in high level. Among the 11 cases with recurrence or metastasis within 6 months after radiotherapy, serum VEGF levels remained high in 9 cases, and decreased serum VEGF level in 1 case after radiotherapy. Conclusion: The level of serum VEGF before radiotherapy is low, the recent curative effect is good, the serum VEGF content is in a high level, which may have potential recurrence or metastasis. The treatment effect is not good recently. Detection of serum VEGF levels of dynamic changes may be the clinical stage of patients with malignant tumors, disease monitoring, observation of the efficacy and prognosis to provide new observations.