放疗抵抗(radioresistance)是导致临床放疗失败的主要原因,严重影响肿瘤患者治疗效果。环氧合酶-2升高产生的乏氧效应、细胞周期阻滞、抑制肿瘤细胞凋亡和促进肿瘤细胞侵袭转移等多种因素都与放疗抵抗密切相关。研究环氧合酶-2与放疗抵抗的关系,并寻找有效应对措施以减少或逆转放疗抵抗是提高放疗疗效的关键。因此,对环氧合酶-2的研究可能成为放疗增敏的新思路和新靶点。 Radiation resistance (radioresistance) is the leading cause of failure of clinical radiotherapy, seriously affecting the treatment of cancer patients. A variety of factors such as hypoxia induced by increased cyclooxygenase-2, cell cycle arrest, apoptosis inhibition and tumor cell invasion and metastasis are all closely related to radioresistance. To study the relationship between cyclooxygenase-2 and radioresistance and to find effective countermeasures to reduce or reverse radiotherapy resistance is the key to improve radiotherapy efficacy. Therefore, the study of COX-2 may become a new idea and a new target of radiosensitization.