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本文报道１９９１年７月楚雄市爆发病毒性心肌炎流行的病原分离和鉴定。本次流行共发病６０余人，死亡１３人。主要临床表现为心慌、胸闷、上腹及胸部疼痛。体征为第一心音低钝、心律不齐、心动过速、血压低等体征。心电图检查有窦过速、多发性多源性室性早搏、Ｔ波低平、低电压等。胸片显示心脏扩大。本次流行发生于夏秋季，患者以青壮年为主，女性多于男性，家庭聚集性明显，发病迅猛，死亡多为猝死。死者主要器官作病理检查呈明显的急性心肌炎及心外膜炎改变。对死者和患者作病原分离，获得柯萨奇Ｂ４和Ｂ６两种病毒。对流行区人群作血清中和抗体检测，发现柯萨奇Ｂ４的中和抗体水平有不同程度的升高。
This article reports the pathogen isolation and identification of the outbreak of viral myocarditis in Chuxiong in July 1991. The prevalence of more than 60 people were reported, 13 people died. The main clinical manifestations of palpitation, chest tightness, abdominal and chest pain. Signs for the first heart sound low blunt, irregular heartbeat, tachycardia, low blood pressure and other signs. Electrocardiographic examination of sinus tachycardia, multiple multi-source ventricular premature beats, T wave low flat, low voltage. Chest radiograph shows enlarged heart. The epidemic occurred in summer and autumn, patients were mainly young and middle-aged, women than men, family aggregation is obvious, the incidence of rapid, mostly sudden death. The pathological examination of the main organs of the deceased showed obvious changes of myocarditis and epicarditis. The dead and patients for pathogenic separation, access to Coxsackie B4 and B6 two viruses. Serum neutralizing antibodies were detected in the endemic areas and the level of neutralizing antibodies of Coxsackie B4 was found to be increased to some extent.