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本文报道美国1972年来,对66例急性非甲非乙型输血后肝炎进行前瞻性研究的6年随访经过。输血后肝炎的诊断标准为接受输血后6个月内连续2次或2次以上、无其他原因解释的SGPT值升高,其中至少一次SGPT高于正常值上限的2倍或5倍。非甲非乙型输血后肝炎的诊断依据是无甲型肝炎(甲型肝炎抗体)及乙型肝炎(HBsAg,抗-HBc或抗-HBs)的血清学证据。在总共94例输血后肝炎中,66例为非甲非乙型肝炎。这组病例有各种不同的疾病背景,均接受大量输血,输血前均无肝病的临床或生化证据。患者一直随访到SGPT值恢复正常(持续3次阴性)或至死亡,或拒绝随访,或迄今。“慢性肝炎”的诊断是以生化异常为根据。如SGPT持续升高超过20周而无禁忌证,则作肝穿刺活检。慢性活动性肝炎(CAH)的组织学依据为碎片样坏死、纤维组织增加和肝小叶内细胞溶解;慢性迁延性
This article reports the United States since 1972, the 66 cases of acute non-A non-B hepatitis B after a prospective study of 6-year follow-up. The diagnostic criteria for post-transfusion hepatitis were two or more consecutive 6 months after receiving the transfusion and SGPT values were interpreted for no other reason, with at least one SGPT greater than two or five times the upper limit of normal. Non-A, B-type hepatitis B is diagnosed on the basis of serological evidence of absence of hepatitis A (Hepatitis A) and hepatitis B (HBsAg, anti-HBc or anti-HBs). Of a total of 94 post-transfusion hepatitis cases, 66 were non-A, non-B hepatitis. This group of patients has a variety of different disease backgrounds, both receiving large amounts of blood transfusions and without clinical or biochemical evidence of liver disease before transfusion. Patients were followed up until SGPT returned to normal (3 negatives) or until death, or refused to follow up, or until now. The diagnosis of “chronic hepatitis” is based on biochemical abnormalities. If SGPT continues to rise for more than 20 weeks without contraindication, liver biopsy is performed. The histological basis of chronic active hepatitis (CAH) is fragmented necrosis, increased fibrosis and intrahepatic lobules cytolysis; chronic persistent