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目的探讨米非司酮与米索前列醇联合清宫术治疗稽留流产患者的临床疗效。方法选取2015年4月至2016年4月辽宁省喀左县妇幼保健所收治的88例稽留流产患者作为研究对象,按照随机数字表法将其分为试验组与对照组,各44例。对照组患者实施乙烯雌酚联合清宫术治疗,试验组患者采用米非司酮、米索前列醇联合清宫术进行治疗。比较两组患者住院时间、术中出血量、妊娠物排出时间、宫颈软化及扩张效果、1次清宫成功率及人工流产综合征发生情况。结果试验组患者住院时间、妊娠物排出时间均明显短于对照组,术中出血量明显少于对照组,差异均有统计学意义(均P<0.05);试验组患者宫颈软化及扩张有效率、1次清宫成功率均明显高于对照组,差异均有统计学意义(均P<0.05);试验组、对照组患者人工流产综合征发生率分别为0.0%(0/44)、18.2%(8/44),差异有统计学意义(χ2=8.80,P=0.003)。结论采用米非司酮、米索前列醇联合清宫术治疗稽留流产临床效果显著,可缩短患者住院时间和妊娠物排出时间,减少术中出血量,改善宫颈软化及扩张效果,提升1次清宫成功率。
Objective To investigate the clinical efficacy of mifepristone combined with misoprostol in the treatment of missed abortion patients. Methods A total of 88 patients with missed abortion admitted in Qiazuo Maternal and Child Health Care Hospital of Liaoning Province from April 2015 to April 2016 were selected as subjects and divided into experimental group and control group with 44 cases in each group according to the random number table method. Patients in the control group were treated with diethylstilbestrol combined with curettage. Patients in the test group were treated with mifepristone and misoprostol combined with curettage. The duration of hospital stay, intraoperative blood loss, time of excretion of pregnancy, cervical softening and dilatation, the success rate of primary clearance and the incidence of induced abortion syndrome were compared between the two groups. Results The hospitalization time and the discharge time of pregnancy in the experimental group were significantly shorter than those in the control group, and the amount of bleeding during operation was significantly less than that of the control group (all P <0.05). The effective rate of cervical softening and expansion in the experimental group (P0.05). The incidence of abortion syndrome in trial group and control group were 0.0% (0/44) and 18.2% respectively, and the success rate of one-time curettage was significantly higher than that of control group (8/44), the difference was statistically significant (χ2 = 8.80, P = 0.003). Conclusion The combination of mifepristone and misoprostol combined with curettage has significant clinical effect in treating missed abortion, which can shorten the hospitalization time and the discharge time of pregnancy, reduce the intraoperative blood loss, improve the effect of cervical softening and expansion, and improve the success of the curettage rate.