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本文用胶态果胶酸铋（ＣＢＰ）合并阿莫西林、甲硝唑三联疗法治疗幽门螺杆菌（ＨＰ）阳性的十二指肠溃疡７３例，并与用胶态次枸椽酸铋（ＣＢＳ）合并阿莫西林＋甲硝唑的三联疗法治疗十二指肠溃疡共７３例进行了随机对照研究，疗程２周，旨在探讨各组ＨＰ的根除率和十二指肠溃疡的愈合率。结果表明，ＣＢＰ及ＣＢＳ两组三联疗法的ＨＰ根除率分别为８３．５６％（６１／７３）和７６．７１％（５６／７３）；ＣＢＰ组的十二指肠溃疡愈合率及有效率分别为８３．５４％（６６／７９）和９７．６４％（７７／７９），ＣＢＳ组的十二指肠溃疡愈合率及有效率分别为７７．６３％（５９／７６）和９４．７３％（７２／７６）。二组的ＨＰ根除率、十二指肠溃疡愈合率及有效率均无显著性差异（Ｐ＞０．１）。治疗后十二指肠溃疡愈合共１１４例，ＨＰ阳性者占１５．８％（１８／１１４），而十二指肠溃疡未愈合的３２例中，ＨＰ阳性率为３４．３８％（１１／３２），两者有显著性差异（Ｐ＜０．０５）。各治疗组均无明显药物不良反应发生。
In this paper, colloidal bismuth pectinate (CBP) combined with amoxicillin and metronidazole triple therapy in the treatment of Helicobacter pylori (HP) positive duodenal ulcer in 73 cases, and colloidal bismuth citrate (CBS ) Combined amoxicillin + metronidazole triple therapy for duodenal ulcer in a total of 73 cases were randomized controlled study, two weeks of treatment, to explore the group of HP eradication rate and healing rate of duodenal ulcer. The results showed that the HP eradication rates of CBP and CBS were 83.56% (61/73) and 76.71% (56/73), respectively. The healing rate and effective rate of duodenal ulcer in CBP group Were 83.54% (66/79) and 97.64% (77/79) respectively. The healing rate and effective rate of duodenal ulcer in CBS group were 77.63% (59/76) and 94.73% (72/76). The two groups of HP eradication rate, duodenal ulcer healing rate and effective rate were no significant difference (P> 0.1). After treatment, duodenal ulcer healed in 114 cases, HP positive accounted for 15.8% (18/114), while 32 cases of duodenal ulcer unhealed, the positive rate of HP was 34.38% (11 / 32), there was a significant difference between the two (P <0.05). Each treatment group had no obvious adverse drug reactions.