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目的探讨腹腔镜手术对卵巢良性肿瘤患者术后免疫功能及神经内分泌激素水平的影响。方法选择2015年2月-2016年6月于深圳市宝安区石岩人民医院收治的232例卵巢良性肿瘤患者为研究对象,依据随机数字表法将其分为对照组和观察组各116例。对照组采用常规开腹手术方案,观察组采用腹腔镜手术方案,比较两组T淋巴细胞亚群及神经内分泌激素(COR、β-EP、ACTH、GLP)水平变化。结果术后24 h及72 h,观察组CD8~+、COR、β-EP、ACTH、GLP水平均低于同时段对照组;观察组CD3~+、CD4~+、CD4~+/CD8~+比值均高于同时段对照组。术后24 h、72 h两组患者COR、β-EP、ACTH和GLP水平均较术前升高,且术后72 h四者水平低于术后24 h;术后24 h、72 h观察组四者水平低于同时段的对照组,差异均有统计学意义(P<0.05)。结论妇科腹腔镜手术对机体内环境的稳定状态影响较小,免疫抑制与内分泌激素波动较为温和,具备相对理想的术后康复条件。
Objective To investigate the effect of laparoscopic surgery on postoperative immune function and neuroendocrine hormone in patients with benign ovarian tumors. Methods A total of 232 patients with benign ovarian tumors who were treated in Shiyan People’s Hospital, Bao’an District, Shenzhen from February 2015 to June 2016 were divided into control group and observation group according to random number table method. The control group received routine laparotomy. The laparoscopic surgery group was used in the observation group. The levels of T lymphocyte subsets and neuroendocrine hormones (COR, β-EP, ACTH, GLP) in the two groups were compared. Results The levels of CD8 +, COR, β-EP, ACTH and GLP in the observation group were lower than those in the control group at 24 h and 72 h after operation. The levels of CD3 +, CD4 +, CD4 + / CD8 + Ratio were higher than the control group at the same time. The levels of COR, β-EP, ACTH and GLP in both groups at 24 h and 72 h after operation were significantly higher than those before operation, and the levels of COR at 72 h postoperatively were lower than those at 24 h postoperatively The levels of the four groups were lower than those of the control group in the same period, the differences were statistically significant (P <0.05). Conclusions Gynecological laparoscopic surgery has little effect on the stable state of the body environment, and the immunosuppressive and endocrine hormones fluctuate more moderately with relatively ideal conditions for postoperative rehabilitation.