目的　探讨Shy Drager综合征 (SDS)的临床特点。方法　对 12例SDS患者的临床资料进行回顾分析。结果　 12例均有发作性晕厥 ,立位血压明显下降 ,而心率变化不大 ;大部分有排尿障碍、性功能下降、锥体系、锥体外系及小脑损害 ,卧位休息多能缓解 ;本组早期均误诊 ,误诊病种多样。本组随访 7例预后不良。结论　自主神经功能异常是SDS的临床特点 ,卧立位血压测定是避免早期误诊的主要措施。 Objective To investigate the clinical features of Shy Drager syndrome (SDS). Methods The clinical data of 12 patients with SDS were retrospectively analyzed. Results All the 12 patients had paroxysmal syncope. The standing blood pressure decreased obviously while the heart rate did not change much. Most of the patients had dysuria, decreased sexual function, cones, extrapyramidal and cerebellum damages. Early misdiagnosis, misdiagnosis of various diseases. The group followed up 7 cases of poor prognosis. Conclusions Autonomic nerve dysfunction is the clinical feature of SDS, lying-position blood pressure measurement is the main measure to avoid early misdiagnosis.