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临床应用的载铜宫内节育器(CuIUD)在植入人体子宫初期会产生明显的铜离子“暴释”现象,为了提高铜的耐蚀性,减缓铜离子的释放速率,采用热氧化法在铜管表面预先制备氧化层。经250～350℃,30～120 min热氧化处理的铜管,采用SEM和XRD观察、分析氧化层表面形貌及其物相组成,由电化学工作站测试不同氧化工艺后样品的腐蚀电位、腐蚀电流密度及交流阻抗谱。根据测试结果优化的氧化工艺参数为275℃×30 min。采用AAS测试并计算了优化工艺处理后氧化样品及其临床应用样品在模拟宫腔液中铜离子的初期释放浓度,结果表明:经275℃×30 min氧化后可得到表面致密、晶粒均匀的氧化层,其物相为Cu2O、CuO,铜离子在模拟宫腔液中的同期最大释放浓度显著低于临床应用样品。因此,采用适宜的热氧化工艺可显著改善CuIUD临床应用中的“暴释”现象。
Clinical application of copper-containing intrauterine device (CuIUD) in the implantation of the human uterus will produce significant copper ion “burst release ” phenomenon, in order to improve the corrosion resistance of copper, slow copper release rate, the use of thermal oxidation Law in the copper surface pre-prepared oxide layer. After thermal oxidation treatment at 250 ~ 350 ℃ for 30 ~ 120 min, the surface morphology and phase composition of the oxide layer were observed by SEM and XRD. The corrosion potential and corrosion of the samples after different oxidation processes were tested by electrochemical workstation Current density and AC impedance spectrum. According to the test results optimized oxidation process parameters 275 ℃ × 30min. AAS was used to test and calculate the initial release concentration of copper ions in the simulated uterine fluid after the oxidation process was optimized. The results showed that after the oxidation at 275 ℃ for 30 min, the surface density and the uniform grains Oxide layer, the phase of Cu2O, CuO, copper ions in simulated uterine fluid in the same period the maximum release concentration was significantly lower than the clinical sample. Therefore, the use of appropriate thermal oxidation process can significantly improve CuIUD clinical application of “burst release” phenomenon.