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目的:测定结直肠癌患者血清血管内皮生长因子(VEGF)的含量,分析其与临床病理指标间的关系。方法:采用ELISA法测定42例初治结直肠癌患者血清VEGF含量,正常对照30例。结果:结直肠癌患者血清VEGF浓度为274.21±218.38 pg/ml,明显高于正常对照组浓度(169.06±68.01 pg/ml,P<0.02),结肠癌患者血清VEGF浓度为346.52±168.57 pg/ml明显高于直肠癌患者(237.31±124.10 pg/ml,P<0.05)。Dukes B、C、D期组患者血清VEGF浓度与对照组相比均有明显差异(P<0.05),Dukes D期组与Dukes A、B、C期组亦均有明显差异(P<0.05)。结直肠癌患者血清VEGF浓度与年龄、性别无相关性(P>0.05)。结论:VEGF与结直肠癌的发生发展及癌肿部位有关,对探讨结直肠癌的发生机制,病情判断,预后及指导治疗有一定价值,对早期诊断似无帮助。
Objective: To determine the serum level of vascular endothelial growth factor (VEGF) in patients with colorectal cancer and analyze its relationship with clinicopathological parameters. Methods: Serum VEGF levels were measured in 42 patients with newly diagnosed colorectal cancer by ELISA, 30 cases of normal control. Results: The serum concentration of VEGF in patients with colorectal cancer was 274.21 ± 218.38 pg / ml, which was significantly higher than that in the normal control group (169.06 ± 68.01 pg / ml, P <0.02). The serum VEGF concentration in patients with colorectal cancer was 346.52 ± 168.57 pg / ml Significantly higher than that of rectal cancer patients (237.31 ± 124.10 pg / ml, P <0.05). The level of serum VEGF in Dukes B, C and D groups was significantly different from that in control group (P <0.05), and there was also significant difference between Dukes D group and Dukes A, B and C groups (P <0.05) . Serum VEGF concentration in patients with colorectal cancer had no correlation with age and sex (P> 0.05). Conclusion: VEGF is associated with the occurrence and development of colorectal cancer and the location of the cancer. It is valuable in exploring the mechanism of colorectal cancer, judging the prognosis and guiding the treatment of colorectal cancer, and may not be helpful in the early diagnosis.