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目的:用灰色理论研究卡托普利缓释片的体外释放过程.方法:采用羧甲基纤维素钠为骨架材料制备缓释片,通过体外释放试验,根据灰色数学模型,预测卡托普利缓释片的体外释放过程.结果:预测值与实测值的平均绝对误差E为0.532,平均相对误差为1.059%.结论:为卡托普利缓释片的临床合理化用药提供了理论依据.
OBJECTIVE: To study the in vitro release process of captopril sustained-release tablets by gray theory.METHODS: The sustained-release tablets were prepared by using sodium carboxymethylcellulose as the matrix material and the release of captopril In vitro release process of sustained-release tablets.Results: The average absolute error of predicted value and measured value E was 0.532, the average relative error was 1.059% .Conclusion: It provides a theoretical basis for clinical rationalization of captopril sustained-release tablets.