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缺氧诱导因子-1(hypoxia-inducible factor-1,HIF-1)是一种依赖于氧调控的转录因子,其在维持氧稳态方面发挥重要作用。缺氧时,缺氧诱导因子-1可以稳定地表达,从而调控一系列缺氧相关基因的表达,其诱导表达的基因与能量代谢、细胞生存与增殖、血管新生、红细胞生成、肿瘤生长以及肿瘤多药耐药等相关。许多心脏疾病都有不同程度的缺氧,机体可对其产生一定程度的代偿。HIF-1是在心肌缺氧中起代偿作用的重要因素,其机制可能涉及缺血缺氧时HIF-1能够促进血管内皮生长因子、诱导型一氧化氮合酶、血红素氧合酶-1、内皮素-1和心房钠尿肽等基因的表达,从而发挥心肌保护作用。
Hypoxia-inducible factor-1 (HIF-1) is an oxygen-dependent transcription factor that plays an important role in maintaining oxygen homeostasis. Hypoxia induces stable expression of hypoxia-inducible factor-1, which regulates the expression of a series of hypoxia-related genes, the genes that it induces expression and energy metabolism, cell survival and proliferation, angiogenesis, erythropoiesis, tumor growth and tumor Multidrug resistance and other related. Many heart diseases have different degrees of hypoxia, the body can produce a certain degree of compensation. HIF-1 is an important factor in the compensation of myocardial hypoxia, the mechanism may be involved in the hypoxia-ischemia HIF-1 can promote vascular endothelial growth factor, inducible nitric oxide synthase, heme oxygenase - 1, endothelin-1 and atrial natriuretic peptide and other gene expression, which play a role in myocardial protection.