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肝纤维化是慢性肝病的共同病理基础,可进一步发展为肝硬化、肝衰竭和门脉高压[1],其本质为肝星状细胞(HSC)的活化和细胞外基质(ECM)的过度沉积[2]。目前认为肝纤维化的形成是由于多种损肝因子,启动炎性细胞,导致HSC激活,活化的HSC事实上是ECM的重要组成成分,通过表达TIMPs减少E
Liver fibrosis is the common pathological basis of chronic liver disease and may further develop into cirrhosis, liver failure and portal hypertension [1], whose essence is activation of hepatic stellate cells (HSC) and excessive deposition of extracellular matrix (ECM) [2]. It is thought that the formation of liver fibrosis is due to a variety of liver damage factor, start inflammatory cells, leading to HSC activation, activated HSC is actually an important component of ECM, by reducing the expression of TIMPs E